解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Modulation of the actin cytoskeleton in chondrocytes has been used to prevent or reverse dedifferentiation and to enhance protein synthesis. We have hypothesized that an actin-modifying agent, staurosporine, could be used with fibrochondrocytes to increase the gene expression and synthesis of critical fibrocartilage p...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-008-0705-6
更新日期:2008-12-01 00:00:00
abstract::Male germ cells of the greater bandicoot rat, Bandicota indica, have recently been categorized into 12 spermiogenic steps based upon the morphological appearance of the acrosome and nucleus and the cell shape. In the present study, we have found that, in the Golgi and cap phases, round spermatid nuclei contain 10-nm t...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-008-0668-7
更新日期:2008-10-01 00:00:00
abstract::The effect of a physiological dose of vitamin C (100 microg/ml) on goat articular cartilage chondrocytes cultured in an alginate matrix and subjected to static pressurization of 2.4 MPa was investigated. Biochemical analyses of DNA, glycosaminoglycan (GAG), collagen and protease activity were carried out in various ma...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-008-0666-9
更新日期:2008-10-01 00:00:00
abstract::The submandibular gland (SMG) is a tissue that can be regenerated in a tissue injury model and that has adult stem cells capable of self-renewal and differentiation into functional cells. We have analyzed the localization of label-retaining cells (LRCs), which are putative progenitor cells, by using the BrdU-labeling ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-008-0667-8
更新日期:2008-10-01 00:00:00
abstract::Although Hertwig's epithelial root sheath (HERS) performs an important function in the formation of the tooth root, the developmental mechanisms that control HERS growth and differentiation remain to be thoroughly elucidated. Bone morphogenetic protein 4 (BMP4), which is secreted by mesenchymal cells, acts on the dent...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-008-0655-z
更新日期:2008-09-01 00:00:00
abstract::Chemoreception in marine invertebrates mediates a variety of ecologically important behaviors including defense, reproduction, larval settlement and recruitment, and feeding. The sensory pathways that regulate deposit-feeding activity by polychaetes living in sedimentary habitats are of particular interest because suc...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-008-0660-2
更新日期:2008-09-01 00:00:00
abstract::The presence, location and degree of immunoexpression of various microfilament (MF) and intermediate filament (IF) systems (actin, cytokeratins, desmin, vimentin) were studied in the excurrent ducts of the testis in sexually mature and active galliform (Japanese quail, domestic fowl, turkey) and anseriform (duck) bird...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-008-0631-7
更新日期:2008-08-01 00:00:00
abstract::Research in mammals has demonstrated a variety of regulatory effects of vasopressin and oxytocin on endocrine functions of the anterior pituitary gland. Less evidence is available regarding the hypophysiotropic action of arginine vasotocin (AVT) comprising vasopressic and oxytocic activities in birds. Some hypophysiot...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-008-0636-2
更新日期:2008-08-01 00:00:00
abstract::Overexpression of type XIII collagen molecules with an 83-amino-acid residue in-frame deletion of part of the ectodomain leads to fetal lethality in Col13a1COL2del transgenic mice. We characterize here the functional disturbances in the cardiovascular system of mouse fetuses overexpressing mutant type XIII collagen. D...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-008-0617-5
更新日期:2008-07-01 00:00:00
abstract::Immediately following the discovery of tryptophan hydroxylase in Drosophila, we demonstrated the presence of tryptophan hydroxylase in the brain of the beetle Harmonia axyridis (Coleoptera: Coccinellidae). However, whether tryptophan hydroxylase is present in the brains of other insects is still a matter of discussion...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-008-0596-6
更新日期:2008-06-01 00:00:00
abstract::Roles of pituitary growth hormone (GH) in female reproduction are well established. Autocrine and/or paracrine actions of GH in the mammalian ovary have additionally been proposed, although whether the ovary is an extra-pituitary site of GH expression in the laying hen is uncertain. This possibility has therefore been...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-008-0595-7
更新日期:2008-05-01 00:00:00
abstract::Mlh1 is a member of DNA mismatch repair (MMR) machinery and is also essential for the stabilization of crossovers during the first meiotic division. Recently, we have shown that zebrafish mlh1 mutant males are completely infertile because of a block in metaphase I, whereas females are fertile but have aneuploid progen...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-007-0550-z
更新日期:2008-04-01 00:00:00
abstract::Aquaporins (AQPs) are integral membrane proteins that function as channels for the transfer of water and small solutes across membranes. In mammalian cells, 13 isoforms (AQP0-12) have been identified, and these exhibit unique patterns of expression in various cell types and tissues. Among these isoforms, AQP6 is consi...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-007-0558-4
更新日期:2008-04-01 00:00:00
abstract::Follicular dendritic cells (FDCs) are immune accessory cells found in the follicles of secondary lymphoid organs where they promote B cell maturation in germinal centers (GCs) that develop following antigen exposure. Recently, we published a method for isolating functional murine FDCs in high purity. We reasoned that ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-007-0566-4
更新日期:2008-04-01 00:00:00
abstract::A gelsolin-related protein was isolated from seminal vesicles of the annelid Lumbricus terrestris. Compared with the isoforms of the gelsolin-related protein previously found in the muscle of the annelid body wall, the isolated protein was assigned to the first isoform (EWAM-P1) because of its electrophoretic mobility...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-007-0561-9
更新日期:2008-04-01 00:00:00
abstract::In developing bioassays for estrogenic effects, vitellogenin (Vtg) induction and zona radiata protein (Zr-protein) induction in males and juveniles of oviparous vertebrates have been used as sensitive biomarkers for estrogenicity. Nonylphenol (NP) produces similar and parallel expression patterns of Vtg and Zr-protein...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-007-0543-y
更新日期:2008-03-01 00:00:00
abstract::CYCLE (CYC) and CLOCK (CLK) are transcriptional activators of the circadian clock genes, period (per) and timeless (tim), binding at E-boxes of their upstream regulatory region in Drosophila. CYC-like and CLK-like immunohistochemical reactivities (CYC-ir and CLK-ir) were investigated in the ground cricket, Allonemobiu...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-007-0534-z
更新日期:2008-02-01 00:00:00
abstract::Osmotic stimulation activates both estivated and inactivated specimens of Helix pomatia and increases their central arousal. High-pressure liquid chromatography has shown that, during activation, the level of both serotonin and dopamine decreases in the central nervous system (CNS) but increases in the foot and heart,...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-007-0522-3
更新日期:2008-02-01 00:00:00
abstract::Ionizing irradiation is an effective treatment for intracranial tumors but is limited by the potential adverse effects induced in surrounding normal brain. These effects can include cognitive impairments, and whereas the pathogenesis of such injury has not yet been definitively established, it may involve injury to th...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
doi:10.1007/s00441-007-0480-9
更新日期:2008-01-01 00:00:00
abstract::The notion that teeth contain stem cells is based on the well-known repairing ability of dentin after injury. Dental stem cells have been isolated according to their anatomical locations, colony-forming ability, expression of stem cell markers, and regeneration of pulp/dentin structures in vivo. These dental-derived s...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
doi:10.1007/s00441-007-0467-6
更新日期:2008-01-01 00:00:00
abstract::This work describes the origin and development of about 200 tension receptor cells located around the anterior attachment site of the locust ovipositor muscle and their migration to their final position on the muscle fibres. The locust ovipositor muscle is the only insect system in which more than 100 tension receptor...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-007-0498-z
更新日期:2007-12-01 00:00:00
abstract::Marked changes in mice pubic symphysis occur by the end of pregnancy. Tissue remodeling involves a dynamic balance between cell proliferation and programmed cell death as well as changes in the extracellular matrix components. Therefore, it is important to consider both of these cellular behaviors when investigating t...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-007-0463-x
更新日期:2007-10-01 00:00:00
abstract::Our previous findings have demonstrated that the rat autosomal-recessive mutation, whitish chalk-like teeth (wct), induces enamel defects resembling those of human amelogenesis imperfecta (AI) in continuously growing incisor teeth. The present study clarifies the effect of the wct mutation on the morphogenesis and cal...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-007-0452-0
更新日期:2007-10-01 00:00:00
abstract::The extracellular matrix (ECM) acts as a critical factor during morphogenesis. Because the organization of the ECM directly influences the structure of tissues and organs, a determination of the way that ECM organization is regulated should help to clarify morphogenesis. We have analyzed the assembly of Del1, an ECM p...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-007-0456-9
更新日期:2007-10-01 00:00:00
abstract::We investigated the actin filament organization and immunolocalization of actin-binding proteins (alpha-actinin and cortactin) in the podocyte foot processes of eight vertebrate species (lamprey, carp, newt, frog, gecko, turtle, quail, and rat). Three types of actin cytoskeleton were found in these foot processes. (1)...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-007-0440-4
更新日期:2007-09-01 00:00:00
abstract::Elastic cartilage-derived cells cultured two-dimensionally with FGF2 and corticosteroid produce gel-type masses that become mature cartilage when injected into a subcutaneous pocket. This unique method has previously been clinically applied for treatments of nasal augmentation. However, the components of the gel-type ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-007-0438-y
更新日期:2007-09-01 00:00:00
abstract::Enterochromaffin (EC) cells regulate gut motility and secretion in response to luminal stimuli, via the release of serotonin (5-HT). Inflammatory bowel disease and other gastrointestinal disorders are associated with increased numbers of EC cells and 5-HT availability. Our aim was to determine whether proliferation of...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-007-0430-6
更新日期:2007-09-01 00:00:00
abstract::Thy-1, a glycophosphatidylinositol-linked glycoprotein of the outer membrane leaflet, has been described in myofibroblasts of several organs. Previous studies have shown that, in fetal liver, Thy-1 is expressed in a subpopulation of ductular/progenitor cells. The aim of this study has been to investigate whether the l...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-007-0437-z
更新日期:2007-09-01 00:00:00
abstract::The maternal-fetal interface, a chimeric structure, is formed when fetal cytotrophoblasts (CTBs) from the placenta invade the uterine wall and its resident vasculature. In preeclampsia (PE), interstitial and endovascular invasion are often shallow, and fewer spiral arterioles are breached in toto. Our previous work ha...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-007-0428-0
更新日期:2007-09-01 00:00:00
abstract::The evolution of aquaporin-5 (AQP5) expression during postnatal development has not been defined in the sweat gland. Previous studies have suggested that AQP isoforms in several peripheral targets are regulated by a neural mechanism. We have examined, in rat sweat glands, the expression of AQP5 during postnatal develo...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-007-0399-1
更新日期:2007-07-01 00:00:00
abstract::PU.1, which is a transcription factor, promotes the terminal differentiation of alveolar macrophages (AMs). Its expression is regulated by granulocyte/macrophage colony-stimulating factor (GM-CSF). In this study of AMs in newborn rats, we performed immunohistochemical staining, acid phosphatase staining, reverse trans...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-007-0405-7
更新日期:2007-07-01 00:00:00
abstract::Box jellyfish have the most elaborate sensory system and behavioural repertoire of all cnidarians. Sensory input largely comes from 24 eyes situated on four club-shaped sensory structures, the rhopalia, and behaviour includes obstacle avoidance, light shaft attractance and mating. To process the sensory input and conv...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-007-0393-7
更新日期:2007-07-01 00:00:00
abstract::Intra-arterial injections of synthetic double-stranded RNA (polyinosinic:polycytidylic acid, PIPC) at a dose of 500 microg/kg evoked pronounced fever in guinea-pigs. PIPC-induced fever could be antagonized by treatment with the non-selective cyclooxygenase (COX) inhibitor diclofenac and was, in part, attenuated by the...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-007-0386-6
更新日期:2007-06-01 00:00:00
abstract::Intracerebroventricular (ICV) injection of melanin-concentrating hormone (MCH) influences feeding behavior in the goldfish and exerts an anorexigenic action in goldfish brain, unlike its orexigenic action in mammals. Despite a growing body of knowledge concerning MCH function in mammals, the role of MCH in appetite ha...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-006-0347-5
更新日期:2007-05-01 00:00:00
abstract::Nitric oxide (NO) stimulates osteoblast differentiation, but whether NO contributes to odontoblast differentiation during dentin repair is unknown. By using reverse transcription/polymerase chain reaction and immunostaining, we investigated the gene expression and/or immunolocalization of endothelial NO synthase (eNOS...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-005-0003-5
更新日期:2007-04-01 00:00:00
abstract::Antisera to the neuropeptides corazonin (Crz) and crustacean cardioactive peptide (CCAP) and to the diapause hormone (DH) react with small sets of neurones in the cephalic ganglia of the crickets Dianemobius nigrofasciatus and Allonemobius allardi. The distribution of their immunoreactivities is similar in the two spe...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-006-0339-5
更新日期:2007-04-01 00:00:00
abstract::Bone marrow (BM) from human and rodent species contains a population of multipotential cells referred to as mesenchymal stem cells (MSCs). Currently, MSCs are isolated indirectly by using a culture step and then the generation of fibroblast colony-forming units (CFU-fs). Unprocessed or native BM MSCs have not yet been...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-006-0292-3
更新日期:2007-03-01 00:00:00
abstract::Recently, an antibody against the choline transporter (CHT), an essential molecule involved in ACh uptake, was used to label cholinergic nerves in the central nervous system; however, the enteric nervous system (ENS) was not examined. The present study localised CHT immunoreactivity (CHT-IR) within the rat ileum ENS a...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-006-0332-z
更新日期:2007-03-01 00:00:00
abstract::Mesenchymal stem cells (MSCs) are increasingly being reported as occurring in a variety of tissues. Although MSCs from human bone marrow are relatively easy to harvest, the isolation of rodent MSCs is more difficult, thereby limiting the number of experiments in vivo. To determine a suitable cell source, we isolated r...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-006-0308-z
更新日期:2007-03-01 00:00:00
abstract::An immunohistochemical staining technique with the D2-40 antibody was undertaken to examine the functional and morphological features of lymphatic networks in tissue sections and whole-mount preparations of normal nasal mucosa and ethmoid sinus mucosa. In normal nasal mucosa, most lymphatic vessels were found in the s...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-006-0337-7
更新日期:2007-03-01 00:00:00